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Bismuth Triflate-Catalyzed Three-Component Mannich-Type Reaction

Thierry Ollevier* and Etienne Nadeau

*Département de chimie, Université Laval, Québec (Québec), Canada G1K 7P4, Email:

T. Ollevier, E. Nadeau, J. Org. Chem., 2004, 69, 9292-9295.

DOI: 10.1021/jo048617c


Bismuth triflate catalyzes the Mannich-type three component reaction of a variety of aldehydes and anilines (leading in situ to aldimines) with silyl enol ethers. The reaction proceeds rapidly and affords the corresponding protected β-amino ketones in high yields.

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Key Words

Mannich Reaction, Multicomponent Reactions, β-Amino Ketones

ID: J42-Y2004-990