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Unexpected Cross-Coupling Reaction between o-Chloroaryl Ketones and Organomanganese Reagents

Gérard Cahiez*, Denis Luart and Fabien Lecomte

*Laboratoire de Chimie Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, 13, Boulevard de l'Hautil, F-95092 Cergy-Pontoise, France, Email:

G. Cahiez, D. Luart, F. Lecomte, Org. Lett., 2004, 6, 4395-4398.

DOI: 10.1021/ol048842g


The mild cross-coupling reaction of alkyl- and arylmanganese reagents with o-chloro- or o-bromoaryl ketones gives substituted ketones in high yields with excellent chemoselectivity.

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Key Words

Ketones, Cross Coupling, Arenes, Biaryls, Organomanganese Reagents

ID: J54-Y2004-1070