Synthesis of Primary Amines by the Electrophilic Amination of Grignard Reagents with 1,3-Dioxolan-2-one O-Sulfonyloxime
Mitsuru Kitamura, Takahiro Suga, Shunsuke Chiba and Koichi Narasaka*
*Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan, Email: narasakachem.s.u-tokyo.ac.jp
M. Kitamura, T. Suga, S. Chiba, K. Narasaka, Org. Lett., 2004, 6, 4619-4621.
DOI: 10.1021/ol0479951 (free Supporting Information)
An electrophilic amination of Grignard reagents with 4,4,5,5-tetramethyl-1,3-dioxolan-2-one O-phenylsulfonyloxime followed by acidic hydrolysis of the resulting imines gives primary amines.
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Electrophilic Amination, Primary Amines