Stereospecific Deoxygenation of Phosphine Oxides with Retention of Configuration Using Triphenylphosphine or Triethyl Phosphite as an Oxygen Acceptor
Hai-Chen Wu, Jin-Quan Yu and Jonathan B. Spencer*
*Department of Chemistry, Cambridge University, Cambridge CB2 1EW, United
Kingdom, Email: jbs20
cam.ac.uk
H.-C. Wu, J.-Q. Yu, J. B. Spencer, Org. Lett., 2004, 6, 4675-4678.
DOI: 10.1021/ol048227c
Abstract
A new, mild protocol for deoxygenation of various phosphine oxides with retention of configuration is described. Mechanistic studies regarding the oxygen transfer between the starting phosphine oxide and triphenylphosphine are also presented.
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Key Words
Desoxygenation, Phosphine Oxides, Phosphines, Silanes, Triethylphosphite, Triphenylphosphine
ID: J54-Y2004-1070
