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Transition Metal Salt-Catalyzed Direct Three-Component Mannich Reactions of Aldehydes, Ketones, and Carbamates: Efficient Synthesis of N-Protected β-Aryl-β-Amino Ketone Compounds

Li-Wen Xu, Chun-Gu Xia* and Lyi Li

*State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, PRC, Email:

L.-W. Xu, C.-G. Xia, L. Li, J. Org. Chem., 2004, 69, 8482-8484.

DOI: 10.1021/jo048778g


The AuCl3-PPh3-catalyzed direct three-component Mannich reactions of aryl aldehydes, aryl ketones, and carbamates led to N-protected β-aryl-β-amino ketones.

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Key Words

Mannich Reaction, Multicomponent Reactions, Amino Ketones, Carbamates

ID: J42-Y2004-1110