Highly Enantioselective Cyanosilylation of Aldehydes Catalyzed by Novel β-Amino Alcohol-Titanium Complexes
Yan Li, Bin He, Bo Qin, Xiaoming Feng* and Guolin Zhang
*Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China, Email: xmfengscu.edu.cn
Y. Li, B. He, B. Qin, X. Feng, G. Zhang, J. Org. Chem., 2004, 69, 7910-7913.
DOI: 10.1021/jo0488356 (free Supporting Information)
A β-amino alcohol-Ti(Oi-Pr)4 complex efficiently catalyzes a mild, enantioselective cyanosilylation of aldehydes. Aromatic, conjugated, heteroaromatic, and aliphatic aldehydes were converted to their corresponding cyanohydrin trimethylsilyl ethers in excellent yields with high enantioselectivities.
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