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Highly Enantioselective Cyanosilylation of Aldehydes Catalyzed by Novel β-Amino Alcohol-Titanium Complexes

Yan Li, Bin He, Bo Qin, Xiaoming Feng* and Guolin Zhang

*Key Laboratory of Green Chemistry & Technology (Sichuan University), Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China, Email:

Y. Li, B. He, B. Qin, X. Feng, G. Zhang, J. Org. Chem., 2004, 69, 7910-7913.

DOI: 10.1021/jo0488356


A β-amino alcohol-Ti(Oi-Pr)4 complex efficiently catalyzes a mild, enantioselective cyanosilylation of aldehydes. Aromatic, conjugated, heteroaromatic, and aliphatic aldehydes were converted to their corresponding cyanohydrin trimethylsilyl ethers in excellent yields with high enantioselectivities.

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ID: J42-Y2004-1150