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Palladium-Catalyzed Tandem Alkenyl and Aryl C-N Bond Formation: A Cascade N-Annulation Route to 1-Functionalized Indoles

Michael C. Willis*, Gareth N. Brace, and Ian P. Holmes

*Department of Chemistry, University of Bath, Bath, BA2 7AY, UK, Email:

M. C. Willis, G. N. Brace, I. P. Holmes, Angew. Chem. Int. Ed., 2005, 44, 403-406.

DOI: 10.1002/anie.200461598

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A new palladium-catalyzed route to N-functionalized indoles has been developed in which the N fragments are introduced in a single-step cascade sequence onto a acyclic carbon framework.

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Key Words

amination, cascade reactions, indoles, nitrogen heterocycles, palladium, Buchwald-Hartwig reaction

ID: J06-Y2005-040