Improved Heteroatom Nucleophilic Addition to Electron-Poor Alkenes Promoted by CeCl₃·7H₂O/NaI System Supported on Alumina in Solvent-Free Conditions

Giuseppe Bartoli, Massimo Bartolacci, Arianna Giuliani, Enrico Marcantoni,* Massimo Massaccesi and Elisabetta Torregiani

*Dipartimento di Scienze Chimiche, Università di Camerino, via S. Agostino 1, I-62032 Camerino (MC), Italy, Email: enrico.marcantoniunicam.it

G. Bartoli, M. Bartolacci, A. Giuliani, E. Marcantoni, M. Massaccesi, E. Torregiani, J. Org. Chem., 2005, 70, 169-174.

DOI: 10.1021/jo048329g (free Supporting Information)

---

Abstract

CeCl₃ • 7H₂O/NaI supported on neutral alumina (Al₂O₃) promotes heteroatom Michael additions under solvent-free conditions. The CeCl₃ • 7H₂O/NaI/Al₂O₃ system works well for hetero-Michael additions of weak nucleophiles such as imidazoles and carbamates to various acceptors.

see article for more examples

---

---

Key Words

Michael Additions, β-Amino Ketones, Sulfides, Carbamates

---

ID: J42-Y2005-070