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Copper-Free Sonogashira Coupling Reaction with PdCl2 in Water under Aerobic Conditions

Bo Liang, Mingji Dai, Jiahua Chen and Zhen Yang*

*Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Beijing 100871, Email:

B. Liang, M. Dai, J. Chen, Z. Yang, J. Org. Chem., 2005, 70, 391-393.

DOI: 10.1021/jo048599z (free Supporting Information)


A mild, copper-free Sonogashira coupling of aryl iodides with terminal acetylenes in water under aerobic conditions has been developed. The use of 1 mol % PdCl2 in the presence of pyrrolidine allows coupling reactions at room temperature or 50C with good to excellent yields.

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Key Words

Sonogashira Coupling

ID: J42-Y2005-090