Thiol-Catalyzed Acyl Radical Cyclization of Alkenals
Kazuya Yoshikai, Tomoharu Hayama, Katsumi Nishimura, Ken-ichi Yamada and Kiyoshi Tomioka*
*Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida,
Sakyo-ku, Kyoto 606-8501, Japan, Email: tomioka
pharm.kyoto-u.ac.jp
K. Yoshikai, T. Hayama, K. Nishimura, K.-I. Yamada, K. Tomioka, J. Org. Chem., 2005, 70, 681-683.
DOI: 10.1021/jo048275a
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Abstract
tert-Dodecanthiol-catalyzed generation of acyl radicals and their intramolecular addition to double bonds gave 2-substituted five- and six-membered cyclic ketones in good yields.
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Key Words
Radical Cyclizations, Cyclopentanones, Cyclohexanones
ID: J42-Y2005-110
