Enantiocontrolled Synthesis of α-Methyl Amino Acids via Bn2N-α-Methylserine-β-lactone
Nicole D. Smith,* Aaron M. Wohlrab and Murray Goodman
*Department of Chemistry, University of California, San Diego, La Jolla, California 92093, Email: smithnuchicago.edu
N. D. Smith, A. M. Wohlrab, M. Goodman, Org. Lett., 2005, 7, 255-258.
DOI: 10.1021/ol047761h (free Supporting Information)
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The regioselective opening of Bn2N-α-methylserine-β-lactone with organocuprates gave enantiopure α-methyl amino acids in excellent yields.
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