Enantiocontrolled Synthesis of α-Methyl Amino Acids via Bn₂N-α-Methylserine-β-lactone

Nicole D. Smith,* Aaron M. Wohlrab and Murray Goodman

*Department of Chemistry, University of California, San Diego, La Jolla, California 92093, Email: smithnuchicago.edu

N. D. Smith, A. M. Wohlrab, M. Goodman, Org. Lett., 2005, 7, 255-258.

DOI: 10.1021/ol047761h

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Abstract

The regioselective opening of Bn₂N-α-methylserine-β-lactone with organocuprates gave enantiopure α-methyl amino acids in excellent yields.

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Key Words

Lactones, Amino Acids, Organocuprates, Regioselectivity

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ID: J54-Y2005-120