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Bismuth Triflate: An Efficient Catalyst for the Formation and Deprotection of Tetrahydropyranyl Ethers

Jacqueline R. Stephens, Phillip L. Butler, Curtis H. Clow, Matthew C. Oswald, Russell C. Smith, Ram S. Mohan*

*Laboratory for Environment Friendly Organic Synthesis, Department of Chemistry, Illinois Wesleyan University, Bloomington, IL 61701, USA, Email:

J. R. Stephens, P. L. Butler, C. H. Clow, M. C. Oswald, R. C. Smith, R. S. Mohan, Eur. J. Org. Chem., 2003, 3827-3831.

DOI: 10.1002/ejoc.200300295

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The tetrahydropyranylation of a variety of alcohols and phenols under solvent-free conditions is efficiently catalyzed by bismuth triflate. This relatively nontoxic catalyst is insensitive to air and small amounts of moisture. Bismuth triflate also catalyzes the deprotection of THP ethers.

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Key Words

Tetrahydropyranyl Ethers

ID: J24-Y2003-1170