A Mild and Efficient Oxidative Deprotection of THP Ethers with NBS in the Presence of β-Cyclodextrin in Water
M. Narender, M. Somi Reddy, K. Rama Rao*
*Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email: drkrraoyahoo.com
M. Narender, M. S. Reddy, K. R. Rao, Synthesis, 2004, 1741-1743.
An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N-bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. A series of tetrahydropyranyl ethers were oxidatively deprotected at room temperature in impressive yields.
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