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A Mild and Efficient Oxidative Deprotection of THP Ethers with NBS in the Presence of β-Cyclodextrin in Water

M. Narender, M. Somi Reddy, K. Rama Rao*

*Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad-500 007, India, Email:

M. Narender, M. S. Reddy, K. R. Rao, Synthesis, 2004, 1741-1743.

DOI: 10.1055/s-2004-829148


An efficient and user-friendly procedure has been developed for the oxidative deprotection of tetrahydropyranyl (THP) ethers with N-bromosuccinimide (NBS) using β-cyclodextrin (β-CD) in water. A series of tetrahydropyranyl ethers were oxidatively deprotected at room temperature in impressive yields.

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Key Words

oxidative deprotection, tetrahydropyranyl ethers, N-bromosuccinimide, β-cyclodextrin, water

ID: J66-Y2004-1320