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Synthesis of Isoquinoline Derivatives Using ROM-RCM of Cyclobutene-yne

Miwako Mori,* Hideaki Wakamatsu, Keisuke Tonogaki, Reiko Fujita, Tsuyoshi Kitamura, and Yoshihiro Sato

*Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan, Email: moripharm.hokudai.ac.jp

M. Mori, H. Wakamatsu, K. Tonogaki, R. Fujita, T. Kitamura, Y. Sato, J. Org. Chem., 2005, 70, 1066-1069.

DOI: 10.1021/jo048214c (free Supporting Information)


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Abstract

ROM-RCM of cyclobutenylmethylamines having an alkyne moiety in a tether afforded isoquinoline derivatives in good yields using a second-generation Grubbs catalyst.

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Key Words

Ring Opening Metathesis, Ring Closing Metathesis, Cyclic Amines, Lactams


ID: J42-Y2005-200