Ligand-Free Palladium-Catalyzed Cyanation of Aryl Halides

Steven A. Weissman,* Daniel Zewge and Cheng Chen

*Department of Process Research, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, Email: steven_weissmanmerck.com

S. A. Weissman, D. Zewge, C. Chen, J. Org. Chem., 2005, 70, 1508-1510.

DOI: 10.1021/jo0481250

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Abstract

K₄[Fe(CN)₆] (a nontoxic cyanide source) allows in combination with 0.1 mol % Pd(OAc)₂ a practical, ligand-free cyanation of aryl bromides in good to excellent yields.

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Key Words

Cyanations

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ID: J42-Y2005-220