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Effects of Catalyst Activation and Ligand Steric Properties on the Enantioselective Allylation of Amines and Phenoxides

Andreas Leitner, Chutian Shu and John F. Hartwig*

*Department of Chemistry, Yale University, P.O. Box 208107, New Haven, Connecticut 6520-8107, Email:

A. Leitner, C. Shu, J. F. Hartwig, Org. Lett., 2005, 7, 1093-1096.

DOI: 10.1021/ol050029d

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The allylic amination and etherification of a broad range of allylic carbonates occurred in high yields and with high regioselectivities and enantioselectivities with an activated metallacyclic iridium catalyst containing a bis-naphthethylamino group.

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Key Words

Allylic Amines, Arylethers

ID: J54-Y2005-270