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Chemoselective Thioacetalization in Water: 3-(1,3-Dithian-2-ylidene)pentane- 2,4-dione as an Odorless, Efficient, and Practical Thioacetalization Reagent

Dewen Dong,* Yan Ouyang, Haifeng Yu, Qun Liu, Jun Liu, Mang Wang and Jing Zhu

*Department of Chemistry, Northeast Normal University, Changchun, 130024, P. R. China, Email:

D. Dong, Y. Ouyang, H. Yu, Q. Liu, J. Liu, M. Wang, J. Zhu, J. Org. Chem., 2005, 70, 4535-4537.

DOI: 10.1021/jo050271y (free Supporting Information)


3-(1,3-dithian-2-ylidene)pentane-2,4-dione has been used as a nonthiolic, odorless 1,3-propanedithiol equivalent in the p-dodecylbenzenesulfonic acid-catalyzed thioacetalization of various aldehydes and ketones in water.

see article for more examples

Chemoselective Thioacetalization Using 3-(1,3-Dithian-2-ylidene)pentane-2,4-dione as an Odorless and Efficient Propane-1,3-dithiol Equivalent under Solvent-Free Conditions

Y. Ouyang, D. Dong, C. Zheng, H. Yu, Q. Liu, Z. Fu, Synthesis, 2006, 3801-3804.

Key Words

1,3-Dithianes, Thioacetalization

ID: J42-Y2005-530