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Copper- and Ligand-Free Sonogashira Reaction Catalyzed by Pd(0) Nanoparticles at Ambient Conditions under Ultrasound Irradiation

Atul R. Gholap, K. Venkatesan, Renu Pasricha, Thomas Daniel, Rajgopal J. Lahoti and Kumar V. Srinivasan*

*Organic Chemistry; Technology Division, and Centre for Material Characterization, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune - 411 008, India, Email:

A. R. Gholap, K. Venkatesan, R. Pasricha, T. Daniel, R. J. Lahoti, K. V. Srinivasan, J. Org. Chem., 2005, 70, 4869-4872.

DOI: 10.1021/jo0503815 (free Supporting Information)


The Sonogashira reaction proceeds efficiently at ambient temperature in acetone or 1,3-di-n-butylimidazolium tetrafluoroborate ([bbim]BF4, a room-temperature ionic liquid) under ultrasound irradiation in the absence of a copper cocatalyst and a phosphine ligand.

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Key Words

Sonogashira Coupling, Ultrasound, Sonochemistry, Ionic Liquids

ID: J42-Y2005-560