N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols
Mohammad Movassaghi* and Michael A. Schmidt
*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email: movassagmit.edu
M. Movassaghi, M. A. Schmidt, Org. Lett., 2005, 7, 2373-2376.
DOI: 10.1021/ol050773y (free Supporting Information)
An amidation of unactivated esters with amino alcohols catalazyed by a stable nitrogen-heterocyclic carbene (NHC) is described. The mechanism is discussed.
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