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N-Heterocyclic Carbene-Catalyzed Amidation of Unactivated Esters with Amino Alcohols

Mohammad Movassaghi* and Michael A. Schmidt

*Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Email:

M. Movassaghi, M. A. Schmidt, Org. Lett., 2005, 7, 2373-2376.

DOI: 10.1021/ol050773y


An amidation of unactivated esters with amino alcohols catalazyed by a stable nitrogen-heterocyclic carbene (NHC) is described. The mechanism is discussed.

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Key Words

Amides, Organocatalysis

ID: J54-Y2005-660