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A Highly Efficient Method for the Reductive Etherification of Carbonyl Compounds with Triethylsilane and Alkoxytrimethylsilane Catalyzed by Iron(III) Chloride

Katsuyuki Iwanami, Hana Seo, Yuki Tobita, Takeshi Oriyama*

*Department of Environmental Sciences, Faculty of Science, Ibaraki University, 2-1-1 Bunkyo, Mito 310-8512, Japan, Email:

K. Iwanami, H. Seo, Y. Tobita, T. Oriyama, Synthesis, 2005, 183-186.

DOI: 10.1055/s-2004-834942


Facile reductive etherification of carbonyl compounds can be conveniently performed by reaction with triethylsilane and alkoxytrimethylsilane catalyzed by iron(III) chloride. The corresponding alkyl ethers, including benzyl and allyl ethers, of the reduced alcohols were obtained in good to excellent yields under mild reaction conditions.

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Key Words

reductive etherification, benzyl ethers, iron(III) chloride, alkoxytrimethylsilane, triethylsilane, carbonyl compounds

ID: J66-Y2005-670