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Synthesis of Tertiary Benzamides via Pd-Catalyzed Coupling of Arylboronic Esters and Carbamoyl Chlorides

Morten LysÚn, Susan Kelleher, Mikael Begtrup and Jesper Langgaard Kristensen*

*Department of Medicinal Chemistry, Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark, Email:

M. Lysen, S. Kelleher, M. Betrup, J. L. Kristensen, J. Org. Chem., 2005, 70, 5342-5343.

DOI: 10.1021/jo050459h (free Supporting Information)


The Pd-catalyzed coupling of ortho-substituted arylboronic esters with carbamoyl chlorides gives tertiary benzamides in good yield.

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ID: J42-Y2005-680