Mild Regioselective Monobromination of Activated Aromatics and Heteroaromatics with N-Bromosuccinimide in Tetrabutylammonium Bromide
Nemai C. Ganguly*, Prithwiraj De, Sanjoy Dutta
*Department of Chemistry, University of Kalyani, Kalyani- 741 235, India,
Email: nemai_g
yahoo.co.in
N. C. Ganguly, P. De. S. Dutta, Synthesis, 2005, 1103-1108.
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Abstract
A highly regioselective bromination of activated aromatic compounds has been accomplished using N-bromosuccinimide in tetrabutylammonium bromide. Predominant para-selective monobromination of activated aromatics, rate acceleration for less reactive substrates on addition of acidic montmorillonite K-10 clay, with or without microwave assistance, are the notable features of this protocol.
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Key Words
bromination, ionic liquids, tetrabutylammonium bromide, N-bromosuccinimide, aromatics, heteroaromatics, regioselectivity
ID: J66-Y2005-740
