Regiospecific Synthesis of 1,4,5-Trisubstituted-1,2,3-triazole via One-Pot Reaction Promoted by Copper(I) Salt
Yong-Ming Wu*, Juan Deng, Ya Li, Qing-Yun Chen
*Chinese Academy of Sciences, 354 Fenglin Rd., Shanghai 200032, P. R. China, Email: ymwumail.sioc.ac.cn
Y.-M. Wu, J. Deng, Y. L. Li, Q.-Y. Chen, Synthesis, 2005, 1314-1318.
see article for more reactions
A method for the regiospecific synthesis of 1,4,5-trisubstituted-1,2,3-triazole catalyzed by copper(I) iodide was developed. This is the first example of a regiospecific synthesis of 5-iodo-1,4-disubstituted-1,2,3-triazole, which can be further elaborated to a range of 1,4,5-trisubstituted-1,2,3-triazole derivatives.
see article for more examples