Ionic Liquid as Catalyst and Reaction Medium. The Dramatic Influence of a Task-Specific Ionic Liquid, [bmIm]OH, in Michael Addition of Active Methylene Compounds to Conjugated Ketones, Carboxylic Esters, and Nitriles
Brindaban C. Ranu* and Subhash Banerjee
*Department of Organic Chemistry, Indian Association for the Cultivation of
Science, Jadavpur, Kolkata 700 032, India, Email: ocbcr
iacs.res.in
B. C. Ranu, S. Banerjee, Org. Lett., 2005, 7, 3049-3052.
DOI: 10.1021/ol051004h
Abstract
The ionic liquid [bmIm]OH is a catalyst and a reaction medium for Michael additions. Although the addition to α,β-unsaturated ketones gives the monoaddition products, this ionic liquid always drives the reaction of open-chain 1,3-dicarbonyl compounds with α,β-unsaturated esters and nitriles toward bis-addition.
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Key Words
Michael addition, ionic liquids, active methylenes, nitro compounds
ID: J54-Y2005-840
