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Pd-Catalyzed Copper-Free Carbonylative Sonogashira Reaction of Aryl Iodides with Alkynes for the Synthesis of Alkynyl Ketones and Flavones by Using Water as a Solvent

Bo Liang, Mengwei Huang, Zejin You, Zhengchang Xiong, Kui Lu, Reza Fathi, Jiahua Chen and Zhen Yang*

*Laboratory of Chemical Genetics, ShenZhen Graduate School, Peking University, Beijing, 100871, China, Email:

B. Liang, M. Huang, Z. You, Z. Xiong, K. Lu, R. Fathi, J. Chen, Z. Yang, J. Org. Chem., 2005, 70, 6097-6100.

DOI: 10.1021/jo050498t


A Pd-catalyzed copper-free carbonylative Sonogashira coupling reaction at room temperature was achieved by using water as a solvent under balloon pressure of CO with Et3N as a base. The developed method was successfully applied to the synthesis of flavones.

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Key Words

Aryl Ketones, Alkynyl Ketones, Sonogashira Coupling, Flavones

ID: J42-Y2005-910