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A Simple and Efficient Heterogeneous Procedure for Thioacetalization of Aldehydes and Ketones

Mohammed Hashmat Ali*, Maria Goretti Gomes

*Chemistry Department, Southeast Missouri State University, Cape Girardeau, MO 63701, USA, Email:

M. H. Ali, M. G. Gomes, Synthesis, 2005, 1326-1332.

DOI: 10.1055/s-2005-865303


A new procedure for the protection of aldehydes and ketones as thioacetals promoted by catalytic amount of p-toluenesulfonic acid and silica gel has been developed. This procedure offers versatility, short reaction time, excellent yield, and is easy to carry out. A simple filtration followed by removal of solvent in most cases produces pure product.

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Key Words

thioacetals, 1,3-dithiolanes, silica gel, heterogeneous, ketones, aldehydes

ID: J66-Y2005-920