Phosphine-Free Palladium Acetate Catalyzed Suzuki Reaction in Water
Leifang Liu, Yuhong Zhang* and Yanguang Wang
*Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China, Email: yhzhangzjuem.zju.edu.cn
L. Liu, Y. Zhang, Y. Wang, J. Org. Chem., 2005, 70, 6122-6125.
DOI: 10.1021/jo050724z (free Supporting Information)
Pd(OAc)2 is an extremely active catalyst for the Suzuki reaction of aryl iodides and bromides in a mixture of water and poly(ethylene glycol) at 50°C. Products are readily isolated by the extraction with diethyl ether, and Pd(OAc)2-PEG can be reused without significant loss in activity.
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S. Shi, Y. Zhang, J. Org. Chem., 2007, 72, 5927-5930.