Ruthenium(III) Chloride-Catalyzed One-Pot Synthesis of 3,4-Dihydropyrimidin-2-(1H)-ones under Solvent-Free Conditions
Surya K. De*, Richard A. Gibbs
*Department of Medicinal Chemistry and Molecular Pharmacology, School of
Pharmacy, Purdue Cancer Center, Purdue University, West Lafayette, IN 47907,
USA, Email: skd125
pharmacy.purdue.edu
S. K. De, R. A. Gibbs, Synthesis, 2005, 1748-1750.
DOI: 10.1055/s-2005-869899
Abstract
Ruthenium(III) chloride efficiently catalyzes the three-component Biginelli reaction of an aldehyde, a β-keto ester, and urea or thiourea under solvent-free conditions to afford the corresponding 3,4-dihydropyrimidine-2-(1H)-ones in excellent yields.
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Key Words
pyrimidinones, ruthenium, aldehyde, Biginelli reaction, solvent-free conditions, heterocycles, multicomponent reactions
ID: J66-Y2005-980
