Lewis Base Catalyzed Ring Opening of Aziridines with Silylated Nucleophiles
Satoshi Minakata, Yuriko Okada, Yoji Oderaotoshi and Mitsuo Komatsu*
*Department of Applied Chemistry, Graduate School of Engineering, Osaka
University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan, Email:
komatsu
chem.eng.osaka-u.ac.jp
S. Minakata, Y. Okada, Y. Oderaotoshi, M. Komatsu, Org. Lett., 2005, 7, 3509-3512.
DOI: 10.1021/ol051186f
Abstract
β-Functionalized sulfonamides were produced in good yields by the regioselective ring opening of N-tosylaziridines with trimethylsilylated nucleophiles, catalyzed by N,N,N',N'-tetramethylethylenediamine (TMEDA).
see article for more examples
Key Words
Aziridines, 1,2-azidoamines, Iodides, Bromides, Nitriles
ID: J54-Y2005-1020
