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A Novel Three-Component One-Pot Reaction Involving Alkynes, Urea or Thiourea, and Aldehydes

Shenlin Huang, Yuanjiang Pan,* Yulin Zhu and Anxin Wu

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, Email:

S. Huang, Y. Pan, Y. Zhu, A. Wu, Org. Lett., 2005, 7, 3797-3799.

DOI: 10.1021/ol051458e (free Supporting Information)


A three-component condensation gave 2-amino-4H-1,3-oxazines or 2-amino-4H-1,3-thiazines from alkynes, urea or thiourea, and aldehydes.

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Key Words

Multicomponent Reactions, N-Heterocycles, O-Heterocycles, S-Heterocycles

ID: J54-Y2005-1160