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One-Step Synthesis of O-Benzyl Hydroxamates from Unactivated Aliphatic and Aromatic Esters

Arnaud Gissot, Alessandro Volonterio and Matteo Zanda*

C.N.R.-I.C.R.M., sezione "A. Quilico" and Dipartimento C.M.I.C. "G. Natta", Politecnico di Milano, via Mancinelli 7, I-20131 Milan, Italy, Email:

A. Gissot, A. Volonterio, M. Zanda, J. Org. Chem., 2005, 70, 6925-6928.

DOI: 10.1021/jo0509713


A simple and high-yielding one-step method for the synthesis of hydroxamates from various unactivated esters (including enolizable esters and chiral α-amino acid esters and peptides) has been developed.

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ID: J42-Y2005-1170