The First Negishi Cross-Coupling Reaction of Two Alkyl Centers Utilizing a Pd-N-Heterocyclic Carbene (NHC) Catalyst

Niloufar Hadei, Eric Assen B. Kantchev, Christopher J. O'Brien and Michael G. Organ*

*Department of Chemistry, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3, Canada, Email: organyorku.ca

N. Hadei, E. A. B. Kantchev, C. J. O'Brien, M. G. Organ, Org. Lett., 2005, 7, 3805-3807.

DOI: 10.1021/ol0514909

---

Abstract

A Pd-NHC catalytic system has been developed, that is capable of cross-coupling various unactivated, primary bromides and alkyl organozinc reagents in high yield at room temperature.

see article for more examples

---

---

Key Words

Negishi Coupling, Alkanes

---

Room-Temperature Negishi Cross-Coupling of Unactivated Alkyl Bromides with Alkyl Organozinc Reagents Utilizing a Pd/N-Heterocyclic Carbene Catalyst

N. Hadei, E. A. B. Kantchev, C. J. O'Brien, M. G. Organ, J. Org. Chem., 2005, 7, 8503-8507.

DOI: 10.1021/jo051304c

---

ID: J54-Y2005-1190