Zn/CuI-Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides
Matthew M. Zhao,* Chuanxing Qu, and Joseph E. Lynch
Process Research, Merck Research Laboratories, Merck & Co., Inc., P.O. Box 2000, Rahway, New Jersey 07065, Email: matthew_zhaomerck.com
M. M. Zhao, C. Qu, J. E. Lynch, J. Org. Chem., 2005, 70, 6944-6947.
A Zn/CuI-mediated coupling of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides is described. Formamide is a superior solvent for obtaining high yields.
see article for more examples