Asymmetric 1,3-Dipolar Cycloaddition Reaction of Nitrones and Acrolein with a Bis-Titanium Catalyst as Chiral Lewis Acid
Taichi Kano, Takuya Hashimoto and Keiji Maruoka*
*Department of Chemistry, Graduate School of Science, Kyoto University,
Sakyo, Kyoto 606-8502, Japan, Email: maruoka
kuchem.kyoto-u.ac.jp
T. Kano, T. Hashimoto, K. Maruoka, J. Am. Chem. Soc., 2005, 70, 11926-11927.
DOI: 10.1021/ja0523284
Abstract
A chiral Ti(IV) catalyst can be successfully utilized in the asymmetric
1,3-dipolar cycloaddition reactions between various nitrones and acrolein to
give the corresponding endo cycloadducts (isoxazolidines) with high to excellent
enantioselectivities.
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Key Words
1,3-Dipolar Cycloaddition, isoxazolidines
ID: J48-Y2005-1260
