Unsymmetrical Ozonolysis of a Diels-Alder Adduct: Practical Preparation of a Key Intermediate for Heme Total Synthesis
Douglass F. Taber* and Katsumasa Nakajima
*Department of Chemistry and Biochemistry, University of Delaware, Newark,
Delaware 19716, Email: taberdf
udel.edu
D. F. Taber, K. Nakajima, J. Org. Chem., 2001, 70, 2515-2517.
DOI: 10.1021/jo001732c
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Abstract
Simple Diels-Alder-derived ketals could be selectively ozonolyzed to
monoaldehydes. An overall procedure for the preparation of a key intermediate
for porphyrin and heme synthesis is described.
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Key Words
ID: J42-Y2001-520
