Organic Chemistry Portal



RuCl3 in Poly(ethylene glycol): A Highly Efficient and Recyclable Catalyst for the Conjugate Addition of Nitrogen and Sulfur Nucleophiles

Huaxing Zhang, Yuhong Zhang*, Leifang Liu, Hailiang Xu, Yanguang Wang

*Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, Email:

H. Zhang, Y. Zhang, L. Liu, H. Xu, Y. Wang, Synthesis, 2005, 2129-2136.

DOI: 10.1055/s-2005-870010


A versatile RuCl3-catalyzed 1,4-conjugate addition of primary, secondary and aromatic amines, thiols, and carbamates to α,β-unsaturated compounds in poly(ethylene glycol) (PEG) provides the desired β-substituted carbonyls in high yields. RuCl3-PEG offers low sensitivity toward moisture and oxygen, high tolerance of different functional groups, and efficient recyclability.

see article for more examples

Key Words

RuCl3, PEG, amines, thiols, conjugate addition (thiols, amines)

ID: J66-Y2005-1280