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One-Pot Copper(I)-Catalyzed Synthesis of 3,5-Disubstituted Isoxazoles

Trond V. Hansen, Peng Wu and Valery V. Fokin*

*Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, Email:

T. V. Hansen, P. Wu, V. V. Fokin, J. Org. Chem., 2005, 70, 7761-7764.

DOI: 10.1021/jo050163b


3,5-Disubstituted isoxazoles are regioselectively obtained in good yields by a mild and convenient one-pot, three-step procedure utilizing a copper(I)-catalyzed cycloaddition reaction between in situ generated nitrile oxides and terminal acetylenes.

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Reaction Pathway

Key Words

Isoxazoles, Cycloaddition

ID: J42-Y2005-1330