An Operationally Simple Base-Catalyzed Multi-component Domino Transformation: Stereoselective Preparation of Trisubstituted Alkenes and 1,3-Dienes
Hadjira Habib-Zahmani, Salih Hacini, Cédric Bories, Robert Faure, Jean Rodriguez*
*Université Paul Cézanne (Aix-Marseille III) , UMR-CNRS-6178-SymBio, Equipe
RéSo, Réactivité en Synthèse organique, Centre de St Jérôme, boîte D12, 13397
Marseille cedex 20, France, Email: jean.rodriguez
univ.u-3mrs.fr
H. Habib-Zahmani, S. Hacini, C. Bories, Robert Faure, J. Rodriguez, Synthesis, 2005, 2151-2156.
DOI: 10.1055/s-2005-869979
Abstract
A versatile and operationally simple base-catalyzed multi-component domino reaction between α,β-unsaturated carbonyl compounds, aldehydes, and alcohols is described, providing a new efficient, and stereoselective one-pot preparation of trisubstituted alkenes and 1,3-dienes.
see article for more examples
proposed mechanism
Key Words
multi-component domino reaction, one-pot synthesis, trisubstituted alkenes, 1,3-dienes
ID: J66-Y2005-1340
