An Aldimine Cross-Coupling for the Diastereoselective Synthesis of Unsymmetrical 1,2-Diamines
Coralie Kison, Nino Meyer, Till Opatz*
*Institut für Organische Chemie, Johannes Gutenberg-Universität Mainz,
Duesbergweg 10-14, 55128 Mainz, Germany, Email: opatz
uni-mainz.de
C. Kison, N. Meyer, T. Opatz, Angew. Chem. Int. Ed., 2005, 44, 5662-5664.
DOI: 10.1002/anie.200501705
Abstract
The selective aldimine cross-coupling represents a simple and flexible method for the synthesis of highly substituted unsymmetrical 1,2-diamines. In addition, either the syn- or anti-configurated vicinal diamine can be obtained, depending on the choice of the workup and reduction conditions.
see article for more examples
Key Words
CC coupling, carbanions, diamines, reduction, umpolung, borane, sodium borohydride, sodium cyanoborohydride
ID: J06-Y2005-1310
