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Palladium-Catalyzed Addition of Arylboronic Acids to Aldehydes

Tetsuya Yamamoto, Tetsuo Ohta* and Yoshihiko Ito

*Department of Molecular Science and Technology, Faculty of Engineering, Doshisha University, Kyotanabe, Kyoto 610-0394, Japan, Email:

T. Yamamoto, T. Ohta, Y. Ito, Org. Lett., 2005, 7, 4151-4155.

DOI: 10.1021/ol051501y


A palladium(0) complex with chloroform is able to catalyze the addition of arylboronic acids to aldehydes in the presence of a base, affording the corresponding secondary alcohols in good yields. A catalytic amount of chloroform seems to be essential for this reaction.

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Key Words

additions, benzylic alcohols

ID: J54-Y2005-1440