Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones
Yonggui Chi and Samuel H. Gellman*
*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, Email: gellmanchem.wisc.edu
Y. Chi, S. H. Gellman, Org. Lett., 2005, 7, 4253-4256.
DOI: 10.1021/ol0517729 (free Supporting Information)
An intermolecular Michael addition of simple aldehydes to nonactivated enones with high enantioselectivities is catalyzed by 5 mol-% diphenylprolinol methyl ether.
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