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Diphenylprolinol Methyl Ether: A Highly Enantioselective Catalyst for Michael Addition of Aldehydes to Simple Enones

Yonggui Chi and Samuel H. Gellman*

*Department of Chemistry, University of Wisconsin, Madison, Wisconsin 53706, Email:

Y. Chi, S. H. Gellman, Org. Lett., 2005, 7, 4253-4256.

DOI: 10.1021/ol0517729


An intermolecular Michael addition of simple aldehydes to nonactivated enones with high enantioselectivities is catalyzed by 5 mol-% diphenylprolinol methyl ether.

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Key Words

Michael Addition, 1,5-Diketones, organocatalysis

ID: J54-Y2005-1500