General Catalysts for the Suzuki-Miyaura and Sonogashira Coupling Reactions of Aryl Chlorides and for the Coupling of Challenging Substrate Combinations in Water
Kevin W. Anderson, Stephen L. Buchwald*
*Department of Chemistry, Room 18-490, Massachusetts Institute of
Technology, Cambridge, MA 02139, USA, Email: sbuchwal
mit.edu
K. W. Anderson, S. L. Buchwald, Angew. Chem. Int. Ed., 2005, 44, 6173-6177.
DOI: 10.1002/anie.200502017I
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Abstract
The use of sulfonated biarylphosphine ligands provides highly active, stable and versatile catalyst systems for Suzuki-Miyaura and Sonogashira cross-coupling reactions in aqueous phase.
Key Words
alkynes, aryl chlorides, arylboronic acids, cross-coupling, water, Suzuki coupling, Sonogashira reaction
ID: J06-Y2005-1510
