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One-Pot Construction of Pyrazoles and Isoxazoles with Palladium-Catalyzed Four-Component Coupling

Mohamed S. Mohamed Ahmed, Kei Kobayashi and Atsunori Mori*

*Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259 Nagatsuta, Yokohama 226-8503, Japan, Email:

M. S. M. Ahmed, K. Kobayashi, A. Mori, Org. Lett., 2005, 7, 4487-4489.

DOI: 10.1021/ol051841j


Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.

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Key Words

Pyrazoles, Isoxazoles, Multicomponent Reactions

ID: J54-Y2005-1540