One-Pot Construction of Pyrazoles and Isoxazoles with Palladium-Catalyzed Four-Component Coupling
Mohamed S. Mohamed Ahmed, Kei Kobayashi and Atsunori Mori*
*Chemical Resources Laboratory, Tokyo Institute of Technology, R1-4 4259
Nagatsuta, Yokohama 226-8503, Japan, Email: amori
res.titech.ac.jp
M. S. M. Ahmed, K. Kobayashi, A. Mori, Org. Lett., 2005, 7, 4487-4489.
DOI: 10.1021/ol051841j
Abstract
Pyrazole or isoxazole derivatives are prepared by a palladium-catalyzed four-component coupling of a terminal alkyne, hydrazine (hydroxylamine), carbon monoxide under ambient pressure, and an aryl iodide.
see article for more reactions
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Key Words
Pyrazoles, Isoxazoles, Multicomponent Reactions
ID: J54-Y2005-1540
