An Easy Two-Step Reduction of Salicylic Acids and Alcohols to 2-Methylphenols
Francesco Mazzini, Piero Salvadori*
*Dipartimento di Chimica e Chimica Industriale, University of Pisa, via Risorgimento 35, Pisa 56126, Italy, Email: lcapdcci.unipi.it
F. Mazzini, P. Salvadori, Synthesis, 2005, 2479-2481.
Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest.
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reductions, deoxygenation, hydrides, phenols, hydrogenations, sodium borohydride