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An Easy Two-Step Reduction of Salicylic Acids and Alcohols to 2-Methylphenols

Francesco Mazzini, Piero Salvadori*

*Dipartimento di Chimica e Chimica Industriale, University of Pisa, via Risorgimento 35, Pisa 56126, Italy, Email:

F. Mazzini, P. Salvadori, Synthesis, 2005, 2479-2481.

DOI: 10.1055/s-2005-872072


Salicylic acids and alcohols can be reduced to 2-methylphenols by a simple two steps procedure. Reaction conditions were optimized carrying out a study on the solvent effect and the amount of the reducing agent. The improved procedure resulted particularly useful in the synthesis of deuterated building blocks of biological interest.

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Key Words

reductions, deoxygenation, hydrides, phenols, hydrogenations, sodium borohydride

ID: J66-Y2005-1610