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Categories: Organic Chemistry >> Synthesis

Catalytic Asymmetric Synthesis

Iwao Ojima

Hardcover, 998 Pages
3rd Edition, 2010
ISBN: 978-0-470-17577-4


This seminal text presents detailed accounts of the most important catalytic asymmetric reactions known today, and discusses recent advances and essential information on the initial development of certain processes. An excellent working resource for academic researchers and industrial chemists alike, the Third Edition features:

Retaining the best of its predecessors but now thoroughly up to date, Catalytic Asymmetric Synthesis, Third Edition serves as an excellent desktop reference and text for researchers and students from the upper-level undergraduates through experienced professionals in industry or academia.

Editorial Review

Iwao Ojima’s "Catalytic Asymmetric Synthesis", 3rd edition, is a worthwhile read for chemists who are interested in the current advances in asymmetric synthesis. Despite the scope implied by the title, only a few research areas are described - the ones that are notable for their current relevance. The length of the book makes possible a remarkably level of detail in the individual chapters, which helps to convey a substantial amount of technical knowledge from the corresponding research areas.

Even though a number of authors have contributed to the work, the resulting book is relatively homogenous and the individual chapters are quite well crafted. Thus, the book can still be recommended to readers who in principle are actually only interested in three or four of the chapters. One needn’t be concerned that the information sought will only be covered superficially, as can often be the case in other works with several authors.

The assortment of synthetic options described is a bit thin, though, which is due to the fact that this 3rd edition is more of an updated supplement to the 2nd and 1st editions. To the extent that the topics presented in the earlier editions are also covered in detail, purchase of the various editions can be recommended as a continuing series. Consultation of the Tables of Contents readily allows one to determine that the amount of overlap has been kept to a minimum.

Still, it is difficult to make a purchase recommendation for a specific edition based on the focus on the topics selected. The reader should make a selection based on the Tables of Contents. Due to the importance of the topics, though, it makes sense for research libraries to have all of the editions available.


1 Catalytic Asymmetric Synthesis in Non-Conventional Media/Conditions (Chikako Ogawa and Shu Kobayashi).
2 Asymmetric Organocatalysis.
2A Enantioselective Organocatalysis Involving Iminium, Enamine, SOMO and Photoredox Activation (Allan J. B. Watson and David W. C. MacMillan).
2B Asymmetric Acid-Base Bifunctional Catalysis with Organic Molecules (Yi Wang and Li Deng).
2C Asymmetric Phase-Transfer and Ion Pair Catalysis (Seiji Shirakawa and Keiji Maruoka).
3 Chiral Lewis Acids and Brřnsted Acids in Asymmetric Synthesis
(Hisashi Yamamoto and Cheol Hong Cheon).
4 Asymmetric Synthesis through C H Activation
(Huw M. L. Davies and Jřrn Hansen).
5 Asymmetric Carbon-Heteroatom Bond-Forming Reactions
(Yoshiji Takemoto and Hideto Miyabe).
6 Enzyme-Catalyzed Asymmetric Synthesis
(Harald Gröger).
7 Transition Metal-Catalyzed Homogeneous Asymmetric Hydrogenation
(Gao Shang, Wei Li and Xumu Zhang).
8 Asymmetric Carbon-Carbon Bond Forming Reactions.
8A Catalytic Asymmetric Conjugate Addition (Jian-Xin Ji and Albert S. C. Chan).
8B Enantioselective Allylic Substitutions with Carbon-Nucleophiles (Günter Helmchen,Uli Kazmaier and Sebastian Förster).
8C Asymmetric Carbometallation and Carbocyclizations (Iwao Ojima, Joseph J. Kaloko, Stephen J. Chaterpaul, Yu-Han Gary Teng and Chi-Feng Lin).
8D Asymmetric Ene Reactions and Cycloadditions (Koichi Mikami and Kohsuke Aikawa).
8E Catalytic Enantioselective Olefin Metathesis Reactions (Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek and Adil R. Zhugralin).
9 Asymmetric Hydrosilation of Carbon-Carbon Double Bonds and Related Reactions
(Jin Wook Han and Tamio Hayashi).
10 Asymmetric Carbonylations
(Cyril Godard, Aurora Ruiz, Montserrat Diéguez, Oscar Pŕmies and Carmen Claver).
11 Asymmetric Oxidations and Related Reactions
(Kazuhiro Matsumoto and Tsutomu Katsuki).
12 Asymmetric Amplification and Autocatalysis
(Kenso Soai, Tsuneomi Kawasaki, and Takanori Shibata).
13 Asymmetric Polymerization
(Shingo Ito and Kyoko Nozaki).