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Categories: Medicinal Chemistry

Contemporary Drug Synthesis

Jie Jack Li, Douglas S. Johnson, Drago R. Sliskovic, Bruce D. Roth

Hardcover, 221 Pages

First Edition, June 2004
ISBN: 0-471-21480-9


An integrated and insightful look at successful drug synthesis in today’s drug discovery market
The pharmaceutical industry is unquestionably vibrant today, with drug synthesis making a vital contribution. Whether in the early developmental stages of identifying and optimizing a lead, or the latter stages of process development and cost-effective scale-up, the ability to design elegant and economical synthetic routes is often a major factor in the eventual viability and commercial success of a drug.

Contemporary Drug Synthesis examines how leading researchers and manufacturers have integrated chemistry, biology, pharmacokinetics, and a host of other disciplines in the creation and development of leading drugs. Authored by four of the pharmaceutical industry’s most respected scientists, this timely volume:

Process chemists provide an essential bridge between chemistry and the marketplace, creating scientifically practical drug processes while never losing sight of the commercial viability of those processes. Contemporary Drug Synthesis meets the needs of a growing community of researchers in pharmaceutical research and development, and is both a useful guide for practicing pharmaceutical scientists and an excellent text for medicinal and organic chemistry students.

Editorial Review

"Contemporary Drug Synthesis" is a highly interesting book that illustrates the syntheses of a number of important drugs. A brief presentation of the associated biological background material is provided for the individual of compound classes, but the synthetic pathways take center stage. When several different pathways are described, the author enumerates the pros and cons of each.

It is noteworthy that the book keeps to the facts, and the emphasis is on an all-inclusive treatment of the extant and significant pathways. While it is true that the number of drugs discussed is limited, the impression is that the most interesting ones have been selected. The reader does need a fairly advanced prior knowledge of organic chemistry in order to derive the most benefit from these readings. "Contemporary Drug Synthesis" doesn't take the place of a textbook, since the comparisons between the different methods and pathways are rather too brief for this purpose.

This work is intended for anyone who is interested in the synthesis of drugs. For students who anticipate specializing in this field, in addition to the traditional medicinal chemistry textbook that provides them with more on the underlying biochemistry, it is recommended that they have a look at this book as well. Even experienced medicinal chemists who consult this work will find themselves inspired with new approaches.


Chapter 1. Antithrombotics: Ticlopidine (Ticlid®) and Clopidogrel (Plavix®).
Chapter 2. Anti-inflammatory Cyclooxygenase-2 Selective Inhibitors: Celecoxib (Celebrex®) and Rofecoxib (Vioxx®).
Chapter 3. H+/K+ -ATPase Inhibitors: Esomeprazole (Nexium®).
Chapter 4. Protein-tyrosine Kinase Inhibitors: Imatnib (Gleevec®) and Gefitinib (Iressa®).
Chapter 5. Non-sedating Antihistamines.
Chapter 6. Cosmeceuticals: Istretinoin (Accutane®), Tazarotene (Tazorac®), Minoxidil (Rogaine®), and Finasteride (Propecia®).
Chapter 7. Antibacterials: Ciprofloxacin (Cipro®) and Linezolid (Zyvox®).
Chapter 8. Atypical Antupsychotics.
Chapter 9. Atovastatin Calcium (Lipitor®).
Chapter 10. Antidepressants.
Chapter 11. Anti-obesity: Orlistat (Xenical®).
Chapter 12. Triptans for Migrane.
Chapter 13. PDE 5 Inhibitors for Erectile Dysfunction: Sildenafil (Viagra®), Vardenafil (Levitra®), and Tadalafil (Cialis®).
Chapter 14. Antiasthmatics.