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Categories: Organic Chemistry >> Synthesis

Domino Reactions in Organic Synthesis

Lutz F. Tietze, Gordon Brasche, Kersten Gericke

Hardcover, 617 Pages
First Edition, 2006
ISBN: 3-527-29060-5


Domino reactions enable you to build complex structures in one-pot reactions - a dream come true. This book provides comprehensive knowledge of this hot field in modern organic chemistry. An approach for an efficiant, economically benificial and ecological benign synthesis.

Editorial Review

The phrase "Domino Reactions" comes from an analogy with a row of domino tiles that falls down sequentially, and refers to a sequence in which chemical bonds are formed one after another. The formation of more than one inter- or intramolecular bond in a single synthesis step enables the elaboration of most highly complex molecules.

The book "Domino Reactions in Organic Synthesis" organizes these reactions according to mechanistic principles in chapters with such titles as “Anionic Domino Reactions”, in which the fundamentals are first explained, followed by several examples from the current literature that await discovery by the reader. It makes sense to classify the reactions from a mechanistic perspective, and provide a brief introduction for each; this is probably the only meaningful way to present these transformations. This monograph is thus better viewed as a textbook or as a source of original ideas rather than as a traditional reference work.

However, it should be emphasized that there are in excess of 1000 literature citations to be found in this book. The majority of the reaction examples are moreover accompanied by mechanistic explanations, so that the reader gleans detailed insights into the design of these domino reactions. Even when the molecules presented are rather complex, one still gains a deep-seated understanding of the mechanisms involved, which will be an advantage when drawing upon one’s own creativity.
This book is aimed at advanced students who are interested in natural product synthesis, but also at the chemists working in research and development who wish to employ these extraordinary reactions to generate complex molecules. Several hundred target structures are included, and certainly the value of this monograph lies in its organization and in the detailed mechanistic presentations. In addition, readers will find themselves astounded by several of the complicated reactions that are covered, which makes this book a very interesting read!


Cationic Transformations
Anionic Transformations
Radical Transformations
Transformations with Carbenes and Nitrenes
Pericyclic Transformations
Photochemical Transformations
Transition Metal Catalysed Transformations