Categories: Organic Chemistry >> Bio

Peptides: Chemistry and Biology

Description

A compact introduction to modern peptide research and a comprehensive reference in one volume. This unique volume covers all the relevant chemical and biological aspects of this wide-ranging field in a concise and easily comprehensible manner. These include the physiological importance, structure, analysis, synthesis, peptide libraries and peptide design. Specialists and experts in particular will profit from the first-class encyclopedic appendix with data on more than 500 physiologically active peptides and proteins.

Editorial Review

No substance class is brought, in this extent, in connection with biological characteristics like peptides. Proteins have a number of extremely important functions for the organism. Peptides as well as peptide mimetics are used as pharmaceuticals. It makes sense to summarize both, the chemistry and the biology of the peptides, in a book, since this has succeeded here in a particularly outstanding way.

This book convinces by many details (e.g. with the glossary) and does not leave any desires open. "Peptides: Chemistry and Biology" presents all important facts about the topic peptides and refers to each chapter to a multiplicity of resuming literature. The book is extremely recommendable for chemists, who work in this area.

Contents

INTRODUCTION AND BACKGROUND
FUNDAMENTAL CHEMICAL AND STRUCTURAL PRINCIPLES
Definitions and main conformational features of the peptide bond
Building blocks, classification and nomenclature
Analysis of the covalent structure of peptides and proteins
Three-dimensional structure
Methods of structural analysis
BIOLOGICALLY ACTIVE PEPTIDES
Occurrence and biological roles
Biosynthesis
Selected bioactive peptide families
PEPTIDE SYNTHESIS
Principles and objectives
Protection of functional groups
Peptide bond formation
Racemization during synthesis
Solid phase peptide synthesis (SPPS)
Biochemical synthesis
SYNTHESIS CONCEPTS FOR PEPTIDES AND PROTEINS
Strategy and tactics
Synthesis in solution
Optimized strategies on polymeric support
Ligation of unprotected peptide segments
SYNTHESIS OF SPECIAL PEPTIDES AND PEPTIDE CONJUGATES
Cyclopeptides
Cystine peptides
Glycopeptides
Phosphopeptides
Lipopeptides
Sulfated peptides
PEPTIDE AND PROTEIN DESIGN, PSEUDOPEPTIDES, PEPTIDOMIMETICS
Peptide design
Modified peptides
Peptidomimetics
Pseudobiopolymers
Macropeptides and de novo design of peptides and proteins
COMBINATORIAL SYNTHESIS
Parallel synthesis
Synthesis of mixtures
APPLICATION OF PEPTIDES AND PROTEINS
Protein pharmaceuticals
Large scale peptide synthesis
Peptide pharmaceuticals
Peptide drugs and new drug assays