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Combinatorial Chemistry - From Theory to Application

W. Bannwarth, B. Hinzen

Hardcover, 672 Pages
Second Edition, 2006
ISBN: 3-527-30693-5


The new edition of this practice-oriented handbook features thoroughly updated contents, including recent developments in parallel synthesis.
A new chapter on screening complements the overview of combinatorial strategy and synthetic methods.

Editorial Review

"Combinatorial Chemistry" is a book that can be recommended with confidence to anyone having an affinity for the subject. This monograph familiarizes young graduate students on the brink of entering the professional phase of their careers with the basic vocabulary and provides an overview of the current methodologies that are important in industrial practice, such as computer-assisted library design and HTS, while understandably focusing on reactions carried out in the solid phase and that employ solid-phase reagents.

The majority of authors come from the industrial sphere, associated with well-known companies dedicated to drug development. It is no empty conceit to state that the wealth of experience and potential being generated by industrial research groups far outstrips that produced by the academic sector. The reader is presented with technical know-how of immediate practicality, in chapters that are relatively focused while still being very interesting to read. In particular, the chapters on C-C bond formation in the solid phase and on the synthesis of heterocycles are well worth reading, and contain a treasure trove of practical advice. For this work the authors deserve high accolades, for they have woven together citations from the current literature, their personal experiences and concrete procedures to make this book an exceptionally rich source of information. Researchers are well-advised to consult the present work before approaching a specific synthesis problem.

"Combinatorial Chemistry" is another in the series of enormously successful works from Wiley-VCH on this theme, particularly solid-phase reactions, such as "Organic Synthesis on Solid Phase" by F. Zaragoza-Dörrwald which we have also recommended recently. In comparing these two monographs, "Organic Synthesis on Solid Phase" contains more information for beginners on the topic of solid-phase synthesis, while "Combinatorial Chemistry" by contrast is focused on important reactions and thus provides more advanced knowledge; it lives up to its title by venturing to provide a more circumspect and comprehensive view.

In contrast to the high quality of the body of the book, it would seem that the introduction written by Bannwarth was incorporated in draft form. The discerning reader is cautioned not to judge the book from a perusal of this faulty front matter.

"Combinatorial Chemistry - From Theory to Application" is recommended to anyone with an interest in this subject, and especially those who seek to delve further into the area of solid-phase synthesis. The present book contains a wealth of practical knowledge; it can save the reader much time spent searching the literature and should shorten the effort of working through the optimization process. It is a splendid reference work, giving the reader ready access to this accumulated expert knowledge.


Purification Principles in High-Speed Solution Phase Synthesis
Linkers for Solid-Phase Organic Synthesis (SPOS) and Combinatorial Approaches on Solid Support
Cyclative Cleavage - A Versatile Concept in Solid-Phase Organic Chemistry
C-C Bond Forming Reactions
Combinatorial Synthesis of Heterocycles
Polymer-Supported Reagents: Preparation and Use in Parallel Organic Synthesis
Encoding Strategies for Combinatorial Libraries
Automation and Devices for Combinatorial Chemistry and Parallel Organic Synthesis
Computer-Assisted Library Design
Assays for High Throughput Screening in Drug Discovery
Appendix: Cheminformatics and Web Resources for Combinatorial Chemistry