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Handbook of Cyclization Reactions

Shengming Ma

Hardcover, 1288 Pages
First Edition, 2009
ISBN: 978-3-527-32088-2
Wiley - VCH


The ultimate and only reference source in this field, this handbook discusses the latest advances on the reactions leading to the formation of cyclic structures and includes chapters presenting the most synthetically attractive cyclization reactions.

Leading chemists from around the world provide authoritative first-hand information, including experimental procedures that offer readers valuable practical information that is otherwise unavailable.

An aid for every organic chemist in grasping and applying these new reactions.

Editorial Review

With its two volumes and a total of 1288 pages, "Handbook of Cyclization Reactions" is quite impressive at first glance. Upon closer examination, the book makes good on much of what it promises: an overview of new cyclization methods. One finds that it is oriented more toward synthetic methods with a lesser focus on structural motifs; consequently, the reader shouldn’t expect to find a concrete solution to a specific synthetic problem, such as a pathway to a desired final compound. The methods are explained in detail, however, and accurately described from the mechanistic standpoint. Thus, it is easy to work through "Handbook auf Cyclization Reactions" and keep possible synthetic strategies in the back of the mind for later access when needed.

The individual chapters contain innumerable examples, good mechanistic illustrations, and even a few concrete synthesis procedures, followed in each case by hundreds of literature citations. This makes the book a good reference work and textbook for advanced students who intend to specialize in the area. Due to the focus on synthetic strategies rather on specific scaffolds, a positive recommendation to purchase this book presumes that the buyer has more of an academic interest in catalysts and new synthetic methods. An overview of all the synthetic methods for five-membered ring heterocycles, for example, could be found in a typical reference work that is organized by molecular skeleton, but would also involve tens of thousands of pages of information.

As editor, Shengming Ma has struck a good compromise in this respect, having limited himself to authors who present interesting new synthetic methods and strategies. The ones who will benefit most from this work are the researchers interested in cyclization reactions who use such methods and the accompanying detailed information creatively. This will be true whether the reader is currently researching new catalysts, or is interested in preparing a broad range of cyclic compounds.!


1. Asymmetric Catalysis of Diels-Alder Reaction (Haifeng Du and Kuiling Ding).
2. Catalytic Asymmetric Aza Diels-Alder Reactions (Yasuhiro Yamashita and Shū Kobayashi).
3. 1,3-Dipolar Cycloaddition (Takuya Hashimoto and Keiji Maruoka).
4. Intramolecular 1,2-Addition and 1,4-Addition reactions (Xiyan Lu and Xiuling Han).
5. Cyclic Carbometallation of Alkenes, Arenes, Alkynes and Allenes (Ron Grigg and Martyn Inman).
6. Transition Metal-Catalyzed Intramolecular Allylation Reactions (Zhan Lu and Shengming Ma).
7. Cyclic Coupling Reactions (Xuefeng Jiang and Shengming Ma).
8. Transition Metal-Mediated [2+2+2] Cycloadditions (David Leboeuf, Vincent Gandon, and Max Malacria).
9. Cyclizations Based on Cyclometallation (Hao Guo and Shengming Ma).
10. Transition Metal Catalyzed Cyclization Reactions of Functionalized Alkenes, Alkynes, and Allenes (Nitin T. Patil and Yoshinori Yamamoto).
11. Ring-Closing Metathesis of Dienes and Enynes (Miwako Mori).
12. Ring-Closing Metathesis of Alkynes (Paul W. Davies).
13. Transition-Metal-Catalyzed Cycloisomerizations and Nucleophilic Cyclization of Enynes (Elena Herrero-Gomez and Antonio M. Echavarren).
14. Cyclopropanation, Epoxidation and Aziridination Reactions (Song Ye and Yong Tang).
15. Cyclization of Cyclopropane- or Cyclopropene-Containing Compounds (Junliang Zhang and Yuanjing Xiao).
16. Transition Metal-Catalyzed Ring Expansion Cyclization Reactions (Masahiro Yoshida and Yoshimitsu Nagao).
17. Hydrometallation-Initiated Cyclization Reactions (Isamu Matsuda).
18. Catalytic Dipolar Cycloadditions of Alkynes with Azides and Nitrile Oxides (Valery V. Fokin).
19. Electrophilic Cyclizations (Félix Rodríguez and Francisco J. Fañanás).
20. Cyclizations Based on C-H Activation (David A. Capretto, Zigang Li, and Chuan He).
21. Friedel-Crafts Type Cyclizations (Ryuji Hayashi and Gregory R. Cook).
22. Macrolactones and Macrolactams (Chang-Liang Sun, Bi-Jie Li, and Zhang-Jie Shi).
23. Free Radical Cyclization Reactions (Jake Zimmerman, Amanda Halloway, and Mukund P. Sibi).
24. Photocyclization Reactions (Axel G. Griesbeck).
25. Asymmetric Organocatalyzed Cyclization Reactions (Liu-Zhu Gong, Jun Jiang, Meng-Xia Xue, and Shi-Wei Luo).